IIPH and I3T

  Anti-Microbial Resistance World Health Organization has declared Anti-Microbial Resistance as one of the top 10  public health concerns worldwide. Misuse and overuse of antimicrobials, inadequate sanitation  facilities, and the absence of proper disease control mechanisms is the main reason for Anti-  Microbial Resistance. Anti-microbials are medicines that can destroy microorganisms having disease-causing  potential. It includes antibiotics, antivirals, antifungals, and antiparasitics. Anti-Microbial  Resistance is basically a phenomenon where our body is resistant to such medicines. Anti-microbial resistance can spread naturally over time from person to person or person to  animal and even plants to animals. Common bacterial infections like urinary tract infections,  sepsis, and sexually transmitted diseases which are frequently treated by antibiotics and show many a time show  resistance to antimicrobials. For example, the rate of resis...

Nuclear Pore Complex: New target for cancer chemotherapy Nuclear pore complexes (NPCs) are the channel-type architecture present in the nucleus of cells. It is the gateway for the transfer of macromolecules (DNA, RNA, and Proteins) from the nucleus to the cytoplasm. Research Scientists at the International Institute of Innovation and Technology Kolkata ( I3TK ) are interested in further research on macromolecular transport machinery for drug development against various metabolic disorders. They identified a novel RNA binding protein (RBP) in a model organism that controls the transport of macromolecules through this channel. Inhibition of this RBP caused destabilization of NPC and mRNA export from the nucleus to the cytoplasm. Many cancer cells exhibited elevated levels of nuclear pores compared to normal cells. A recent study from Sanford Burnham Prebys Medical Discovery Institute demonstrated that blocking the construction of nuclear pores complexes shrank aggressive tumors in mice ...